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To keep pace with the increase in the rate of mitochondrial iron import and ALAS activity during terminal erythropoiesis, the processes necessary for activation of PPOX and the intermediate enzymes of the heme synthesis pathway must also be upregulated to keep pace with heme synthesis and to minimize the accumulation of cytotoxic heme intermediates

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29: 10031026.CrossRefGoogle ScholarPubMed Castillo-Lancellotti, C, Tur, J, Uauy, R

Detecting attenuation requires repeated measurements at the start of dosing and again after weeks of steady-state exposure, in the same individuals